Durham County Council will be carrying out resurfacing work on the south-bound section of the A690 dual carriageway, between the county border with Sunderland and Rainton Gate.
The work will start on Monday (Nov 23) and is expected to take six days.
During the work a contraflow system will operate on the north-bound carriageway of that section of the road and five central reservation crossover points will be closed.
Diversion routes for residents in West Rainton and Rainton Gate will be in place.
John Reed, head of technical services at Durham County Council, said: “This work is part of our essential maintenance programme which is aimed at keeping the county’s roads in good condition.
“We appreciate that this is a busy commuter route in and out of Durham and we would ask road users to be patient and allow extra time for their journeys while we carry out this work.”